pkotecha-eng/aria-mcp-server

A standalone MCP server that gives any Claude agent real-time access to biomedical literature and clinical trials — no API keys required.
Tools
| Tool | Description |
|------|-------------|
| search_pubmed | Search 35M+ peer-reviewed papers via NCBI E-utilities |
| search_clinical_trials | Search 400K+ trials via ClinicalTrials.gov v2 API |
| search_isrctn | Search UK/European trials via ISRCTN registry |
Prompts
| Prompt | Description |
|--------|-------------|
| clinical-research-brief | Comprehensive evidence + trial brief for a condition |
| adverse-event-analysis | Structured AE and safety profile for a drug |
| trial-eligibility-checker | Patient eligibility assessment across recruiting trials |
Resources
| Resource | Description |
|----------|-------------|
| info://aria | Overview of ARIA capabilities and data sources |
| reference://trial-phases | Phase I–IV definitions and FDA special designations |
| reference://high-impact-journals | Curated high-impact journals by specialty |
| reference://fda-databases | FDA databases for drug, safety, and regulatory research |
Example queries
Once connected, ask Claude:
- "Search PubMed for ketogenic diet pediatric epilepsy outcomes"
- "Find recruiting trials for lung cancer immunotherapy"
- "What does the literature say about veliparib in ovarian cancer, and are there active trials?"
- "Find UK and European trials for pediatric epilepsy via ISRCTN"
Quickstart
Connect to Claude Desktop
Add to ~/Library/Application Support/Claude/claude_desktop_config.json:
Restart Claude Desktop. The server will appear under Settings → Developer → Local MCP Servers.
Data sources
- **PubMed** — NCBI E-utilities (public API, no key required)
- **ClinicalTrials.gov** — v2 REST API (public API, no key required)
- **ISRCTN** — UK/European clinical trials registry (public API, no key required)
Tech stack
- FastMCP — MCP server framework
- Python 3.12+
Use cases
- Life sciences researchers needing real-time literature access
- Clinical trial coordinators checking eligibility and recruiting status